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Benztropine mesylate

Catalog No. T1336Cas No. 132-17-2
Alias Benztropine methanesulfonate, Benzotropine mesylate, Benzatropine mesylate

Benztropine mesylate (Benztropine methanesulfonate) is a centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine.

Benztropine mesylate

Benztropine mesylate

Purity: 100%
Catalog No. T1336Alias Benztropine methanesulfonate, Benzotropine mesylate, Benzatropine mesylateCas No. 132-17-2
Benztropine mesylate (Benztropine methanesulfonate) is a centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine.
Pack SizePriceAvailabilityQuantity
500 mg$29In Stock
1 mL x 10 mM (in DMSO)$30In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Benztropine mesylate (Benztropine methanesulfonate) is a centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine.
Targets&IC50
DAT:118 nM
In vitro
At doses of 5 mg/kg and 25 mg/kg, Benztropine increases the levels of extracellular dopamine in the striatum of rats in a dose-dependent manner. A daily dose of 3 mg of Benztropine effectively improves tremor and motor scores in patients with Parkinson's disease on the Unified Parkinson's Disease Rating Scale without causing adverse effects such as leukopenia.
In vivo
In HEK-293 cells treated with [3H]CFT and under the condition of 130 mM sodium ions, the D313N DAT exhibited a slight increase in the apparent equilibrium dissociation constant for Benztropine. The double mutant W84L D313N DAT showed a similar apparent equilibrium dissociation constant for Benztropine when compared to the single mutation. Benztropine inhibited MTSET-induced binding of [3H]WIN to the wild-type dopamine transporter with an EC50 of 28 μM in a concentration-dependent manner. Furthermore, Benztropine demonstrated a protection rate of 32 in the X-A342C DAT construct by shielding Cys-342 from reactivity (EC50 for inhibition of [3H]WIN (4 nM) to IC50 binding).
AliasBenztropine methanesulfonate, Benzotropine mesylate, Benzatropine mesylate
Chemical Properties
Molecular Weight403.53
FormulaC21H25NO·CH4SO3
Cas No.132-17-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 74 mg/mL (183.4 mM)
DMSO: 45 mg/mL (111.52 mM), Sonication is recommended.
Ethanol: 75 mg/mL (185.9 mM)
Solution Preparation Table
DMSO/H2O/Ethanol
1mg5mg10mg50mg
1 mM2.4781 mL12.3907 mL24.7813 mL123.9065 mL
5 mM0.4956 mL2.4781 mL4.9563 mL24.7813 mL
10 mM0.2478 mL1.2391 mL2.4781 mL12.3907 mL
20 mM0.1239 mL0.6195 mL1.2391 mL6.1953 mL
50 mM0.0496 mL0.2478 mL0.4956 mL2.4781 mL
100 mM0.0248 mL0.1239 mL0.2478 mL1.2391 mL

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